In 1876, a group of donors joined forces with skilled medical professionals to establish the Charlotte Home and Hospital of St. Peter's Episcopal Church in two rented rooms on East 7th Street. From this humble beginning grew one of the region's greatest medical treasures.

When St. Peter's Hospital expanded in 1898, children's needs were considered in the move. The hospital designed a special room "with a view to a child's pleasure and comfort," an unusual sentiment in the era of "children are meant to be seen, not heard." By 1905, the hospital provided complimentary healthcare for the children of Thompson Orphanage and, in 1922, added a children's unit and a babies' unit.

In the 1940s, the City of Charlotte assumed control of the hospital, which was moved to its present campus and renamed Charlotte Memorial Hospital. Through philanthropic support, the hospital added five cribs and five youth beds, with priority given to children from the mountains of the Carolinas and crippled children under the age of 14.

Over time, Charlotte Memorial grew into Carolinas Medical Center, providing healthcare to the entire region. In 1989, the hospital evaluated children's healthcare needs and decided it was time to consolidate and create a 'hospital-within-a-hospital' dedicated to children. In 1992, Carolinas Medical opened The Children's Hospital, the first children's facility of its kind in the region. The results have proven that this type of family-centered, concentrated focus on children is the right approach to children's healthcare. The Levine Children's Hospital, which opened in 2007, was the logical next step in a journey that is well into its second century of providing the finest healthcare available to the families of the Carolinas.